SPR-BI 4000 Series
Key Features • Temperature controlled two-channel SPR detection module
Covers wide SPR angle range for measuring SPR shift in liquid phase. Precision background and reference subtraction. Temperature control for thermodynamic studies, 6 to 50 °C.
• Fully- and Semi-automated options with
BI-DirectFlow™ Technology For ultra-fast kinetics, discernment of secondary effects, and generation of high quality results. Available in fully-automated option with BI Autosampler.
• Innovative multi-module design
Provides users with maximum flexibility to choose amongst various analysis modules for diverse applications
• Compatible with electrochemistry applications
Allows for electrochemical SPR studies and chemical sensor research.
• Single and dual channel flow modes
Allows for more experimental options and enhanced data quality
• Wide dynamic range and high sensitivity
High sensitivity (<10-5 degrees) for both large and small molecules (<100 Daltons) enables users to measure binding constants down to a few pM-1
• Broad response time
For slow (hours) and fast (< 0.5 ms) kinetic processes
Analysis Modules Included: BI-DirectFlow™ Module
for advanced two-channel ultra-fast kinetics research
Optional Accessories: EC-DualFlow™ Module
for advanced two-channel electrochemical (EC) flow SPR research
EC-SPR Module
for electrochemical (EC) SPR research
BI Sensor Chips
with high uniformity for reproducible SPR research
System Specifications: SPR Base Station
Temperature Controlled Two-Channel SPR Detection Unit Differential detection electronics for high sensitivity and fast detection
Broad detection range for measuring SPR binding in liquid phase Accurate background and reference subtraction Broad response window for slow and fast kinetics analysis Visual SPR profile for SPR quality and chip evaluation Temperature control for thermodynamic studies
Versatile in Application
One instrument for numerous applications
Interchangeable analysis modules for different research needs Accessible detection area and auxiliary data ports to facilitate project integration Small footprint to save valuable lab space USB connectivity for convenient transportability
Fluid Handling Semi-automated sample delivery with BI-DirectFlow™
For two-channel precision sample delivery
Near-zero sample dispersion for fast kinetics and high resolution binding analysis Single and serial flow modes Continuous flow stream for uninterrupted binding studies Zero-dead volume injection valves for negligible sample carry over HPLC-type components for convenient and low cost maintenance Autosampler for automated sample preparation and delivery (optional) Precision Syringe Pump
Two-channel programmable syringe pump for uniform continuous flow
Wide flow range (depending upon syringe size) Accurate and steady flow resulting in stable baselines and high quality data Quiet and easy operation Control System
Control/Analysis Software
Powerful and easy-to-use software package
Collect SPR data in real-time Programmable injection timers for accurate sample delivery Easily manage and/or overlay multiple data files Smart Wizards to guide user through instrument operation Powerful analysis tools to evaluate binding interactions, i.e. affinity, kinetics, concentration, and mass loading Tools to compensate for bulk refractive index shift, non-specific adsorption, mass limited transport, noise, and more Select amongst various SPR operational modes for optimized performance, i.e. flow injection, EC, and more. Computer
PC with pre-installed BI software package
Windows 7 operating system Ethernet connectivity (direct on-line customer support available) USB connectivity to BI-SPR instruments for transportability
Applications: Life Science
Our Flow injection technique and analysis modules can help you with drug discovery and development, protein-protein/ protein-DNA/ protein-drug interaction studies, gene assays, immunosensing, and more.
Electrochemistry
Our Electrochemical SPR technique and analysis modules can help you with a variety of electro-analytical applications such as anodic stripping analyses, electropolymerization, electrodeposition, redox-related conformational change, and more.
Chemical Vapor Sensing
Our Gas Phase SPR technique and analysis modules can help you study fundamental solid-gas interface interactions, detect toxic molecules in the environment, perform various chemical analyses for medical research, and more.
Environment, Food & Beyond
Our BI-SPR techniques can help you with broader applications such as food safety, quality control, environmental monitoring, or the development of new high-performance and coupled SPR techniques.
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